Abstract #0551

Accurate MR Thermometry by Hyperpolarized 129Xe

Le Zhang^1,2, Alex Burant^2,3, Andrew McCallister^2,3, Karl Koshlap⁴, Simone Degan⁵, Michael Antonacci^2,3, and Rosa Tamara Branca^2,3

¹Department of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ²Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ³Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ⁴Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ⁵Center for Molecular and Biomolecular Imaging, Duke University, Durham, NC, United States

A new thermometry method based on the temperature dependence of lipid-dissolved ¹²⁹Xe was proposed, while its accuracy was assessed by direct comparison with Proton Resonance Frequency (PRF) based MR thermometry methods. The temperature dependences of chemical shifts of lipid-dissolved ¹²⁹Xe, water and methylene spins were first measured in vitro with high accuracy on various fat-rich tissues. The results were then used to obtain relative temperature maps in vivo in mice acclimated at different temperatures. Lipid-dissolved ¹²⁹Xe based MR thermometry demonstrated superior accuracy in both in vivo and in vitro results when compared to PRF based MR thermometry in fatty tissues.

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