Evaluation of thermal ablation with a 230 kHz transcranial MRI-guided focused ultrasound system in a large animal model
Nathan McDannold1, Jonathan Sutton1, Natalia Vykhodtseva1, and Margaret Livingstone2
1Radiology, Brigham and Women's Hospital, Boston, MA, United States, 2Neurobiology, Harvard Medical School, Boston, MA, United States
This work evaluated the feasibility of thermal ablation in
the brain in nonhuman primates using a 230 kHz transcranial MRI-guided focused
ultrasound system. We aimed to determine whether using this low frequency can
expand the treatment envelope where focused ultrasound can be used in the brain
without overheating the skull. We found that focal heating was increased and
skull heating decreased compared to prior work in macaques that tested a higher
frequency version of this system, suggesting that it can indeed increase this
envelope. Furthermore, closed-loop feedback maintained a low level of
cavitation activity.
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