Abstract #0565

Local shape analysis of the thalamus in extremely preterm born young adults

Eliza Orasanu¹, Andrew Melbourne¹, Zach Eaton-Rosen¹, David Atkinson², Joshua Lawan³, Joanne Beckmann⁴, Neil Marlow⁴, and Sebastien Ourselin¹

¹Translational Imaging Group, Centre for Medical Image Computing, University College London, London, United Kingdom, ²University College London, London, United Kingdom, ³University College Hospital, London, United Kingdom, ⁴Institute for Women's Health, University College London, London, United Kingdom

Alterations of thalamic structures may cause disruptions in thalamic-cortical-thalamic circuitry and affect cognition. In this work we present a local shape analysis of the thalamus in extremely preterm born young adults when compared to their term born peers. We perform a groupwise shape analysis after spectral matching registration. After correcting for gender and thalamic volume, it resulted that the anterior and superior thalamic regions, connected to regions responsible for executive function, working memory, language and verbal memory, show most shape variations.

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