Abstract #0568

Simultaneous T2, T2' and PDFF mapping in the spine using an adiabatic T2-prepared time-interleaved multi-echo gradient echo acquisition

Stefan Ruschke¹, Dominik Weidlich¹, Maximilian Diefenbach¹, Holger Eggers², Hendrik Kooijman³, Houchun H. Hu⁴, Ernst J. Rummeny¹, Axel Haase⁵, Jan S. Kirschke⁶, Thomas Baum¹, and Dimitrios C. Karampinos¹

¹Department of Diagnostic and Interventional Radiology, Technische Universität München, Munich, Germany, ²Philips Research, Hamburg, Germany, ³Philips Healthcare, Hamburg, Germany, ⁴Radiology, Phoenix Children’s Hospital, Phoenix, AZ, United States, ⁵Zentralinstitut für Medizintechnik, Technische Universität München, Garching, Germany, ⁶Neuroradiology, Technische Universität München, Munich, Germany

Simultaneous T2 and T2ʹ mapping is highly desirable in applications investigating changes in blood oxygenation, iron content and bone mineral density. Simultaneous T2 and T2ʹ mapping is highly desirable in applications investigating blood oxygenation changes (in tumors), iron deposition (in patients with blood transfusions) and trabecular bone matrix weakening (in osteoporosis patients). Gradient echo imaging using adiabatic T2-preparation has enabled T2 mapping in the presence of inhomogeneous B1 fields. In addition, the presence of water and fat components has to be considered in the extraction of T2 and T2ʹ parameters in many organs. The simultaneous quantification of the proton-density fat fraction (PDFF) can be also of particular interest (e.g. in the liver and in, fat fraction, bone marrow fat fraction). Multi-echo gradient echo imaging can separate water and fat components and quantify PDFF. Therefore, the purpose of the present work was to introduce a novel method for simultaneous T2, T2ʹ and PDFF mapping, relying on an adiabatic T2-preparation combined with a time-interleaved multi-echo gradient echo acquisition scheme.

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