VERDICT (Vascular, Extracellular, and Restricted Diffusion for Cytometry in Tumours) is a microstructural imaging technique that has shown significant potential in preclinical and pilot studies. However, its technical repeatability is unknown and must be established for translational and clinical application.
5 patients underwent consecutive VERDICT acquisitions, and their quantitative parametric maps were compared in tumour and non-tumour regions. We found that cellularity was the most reliable parameter, with almost perfect repeatability in both normal and cancerous prostate tissue. Intra and extracellular volume fractions also performed well, with almost perfect repeatability in the normal prostate and excellent repeatability in cancerous tissue.