Transient Oxygen Extraction Fraction as a Measure of Cerebrovascular Reserve
Charles G Cantrell1, Parmede Vakil1,2, Donald R Cantrell3, Yong Jeong1, Sameer A Ansari3, and Timothy J Carroll1,3
1Biomedical Engineering, Northwestern, Chicago, IL, United States, 2College of Medicine, University of Illinois, Chicago, IL, United States, 3Radiology, Northwestern, Chicago, IL, United States
We have found that MR-PARSE has detectable sensitivity to frequency shifts induced by transient alterations in de-oxyhemoglobin through the cardiac cycle. Our initial studies have shown, through the use of ICA, a statistically significant hemispheric difference between healthy and compromised regions. Our approach to quantifying cerebrovascular reactivity represents a new and simple, non contrast approach to stratifying patients toward therapies to prevent stroke.
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