Abstract #0626

Intravoxel incoherent motion diffusion-weighted imaging of hepatocellular carcinoma: is there a correlation with flow and perfusion metrics obtained with dynamic contrast-enhanced MRI?

Stefanie Hectors¹, Mathilde Wagner¹, Cecilia Besa¹, Hadrien Dyvorne¹, Octavia Bane¹, M. Isabel Fiel², Hongfa Zhu², and Bachir Taouli^1,3

¹Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States

We assessed the correlation between intravoxel incoherent diffusion-weighted imaging (IVIM-DWI) and dynamic contrast-enhanced MRI (DCE-MRI) in hepatocellular carcinoma (HCC) and liver parenchyma. DCE-MRI-derived arterial fraction and arterial flow were significantly negatively correlated with IVIM-DWI-derived perfusion fraction and pseudodiffusion in the liver, while IVIM-DWI parameters did not correlate with DCE-MRI parameters in HCC. These results indicate that IVIM-DWI and DCE-MRI provide non-redundant information in HCC.

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