Meeting Banner
Abstract #0650

Arterial transit time (ATT) heterogeneity in calf muscle: how DCE studies reveal a critical challenge for arterial spin labeling (ASL) acquisition

Jeff L. Zhang1, Christopher Hanrahan1, Christopher C. Conlin1, Corey Hart2, Gwenael Layec2, Kristi Carlston1, Daniel Kim1, Michelle Mueller3, and Vivian S. Lee1

1Radiology, University of Utah, Salt Lake City, UT, United States, 2Internal Medicine, University of Utah, Salt Lake City, UT, United States, 3Vascular surgery, University of Utah, Salt Lake City, UT, United States

One major challenge for measuring exercise perfusion of skeletal muscle with ASL is the potential heterogeneity of arterial transit time (ATT) across the muscle. In this study, we used reliable DCE MRI technique to measure ATT of calf muscle in both healthy controls and peripheral artery disease patients and after plantar flexion of different loads. Our study showed that ATT of calf muscle varied with multiple factors, including muscle group, exercise load and healthy status, and had a wide range of 0~4 sec. The result suggests the necessity of performing calf-muscle ASL with multiple different post-labeling delays.

This abstract and the presentation materials are available to members only; a login is required.

Join Here