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Abstract #0652

High temporal resolution DCE MRI of breast cancer treated with neo-adjuvant chemotherapy and analyzed with both distributed parameter and modified Tofts tracer kinetics models

Dennis Lai-Hong Cheong1, Bo Zhang1, Bingwen Zheng1, Limiao Jiang1, Eugene Wai Mun Ong2, Soo Chin Lee3,4, and Thian C Ng1

1Clinical Imaging Research Centre, A*STAR-NUS, Singapore, Singapore, 2Department of Diagnostic Imaging, National University Hospital in Singapore, Singapore, Singapore, 3Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore, Singapore, 4Cancer Science Institute of Singapore, Singapore, Singapore

Higher resolution DCE-MRI is readily attainable and should allow for more realistic distributed parameter tracer kinetics models to be used. However, simpler, faster and lesser parameters compartmental models such as the modified Tofts model are still preferred by many researchers. We present here how we have implemented a distributed parameter model to analyze 2.4sec/frame DCE MRI data in a clinical trial of neo-adjuvant chemotherapy with or without short-course anti-angiogenic therapy in breast cancer patients. The results from modified Tofts and the distributed parameter model differ. More realistic distributed parameter models might be better in analyzing high temporal resolution DCE-MRI data.

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