Meeting Banner
Abstract #0669

Metabolic imaging of energy metabolism in traumatic brain injury using hyperpolarized [1-13C]pyruvate

Stephen J DeVience1, Xin Lu1, Julie Proctor2, Parisa Rangghran2, Rao Gullapalli1, Gary M Fiskum2,3,4, and Dirk Mayer1

1Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, MD, United States, 2Anesthesiology, University of Maryland, Baltimore, MD, United States, 3Biochemistry and Molecular Biology, University of Maryland, Baltimore, MD, United States, 4Pharmacology, University of Maryland, Baltimore, MD, United States

We investigated the use of hyperpolarized 13C-pyruvate imaging as a direct, non-invasive method for identifying traumatic brain injury and studying its effects on energy metabolism. Rats were injured with a controlled cortical impact device and then injected with [1-13C]pyruvate. Spectrally-resolved imaging was performed on the brain to quantify the resulting pyruvate, lactate, and bicarbonate signals. The ratio of lactate to bicarbonate signal was found to be sensitive to traumatic brain injury, with the relative increase in lactate signal and decrease in bicarbonate (formed from CO2) at the injury site suggesting a transition to anaerobic respiration.

This abstract and the presentation materials are available to members only; a login is required.

Join Here