Tumor Progression, Regression, and Recurrence Monitoring using Hyperpolarized [1-13C]Pyruvate Metabolic Imaging in a Murine Breast Cancer Model
Peter jinwoo Shin1, Zihan Zhu1, Roman Camarda2, Robert Bok1, Alicia Zhou2, Andrei Goga2, and Daniel B Vigneron1
1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Biomedical Science Program, University of California, San Francisco, San Francisco, CA, United States
We used hyperpolarized [1-13C]pyruvate imaging to monitor tumor progression
and regression in a murine breast cancer model that conditionally expresses the
human c-MYC transgene in a
doxycycline switchable manner. Previously, it was shown that this model could
develop a secondary tumor even after the primary tumor regresses nearly fully following
c-MYC deinduction. Hence, the purpose of this project was to
monitor altered glycolytic metabolism by hyperpolarized metabolic MRI in this
multi-stage mammary tumorigenesis animal model.
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