Abstract #0677

On the Feasibility of Quantitative Susceptibility Mapping For Trabecular Bone Volume Density Mapping at 3 T

Maximilian Nikolaus Diefenbach¹, Anh T. Van², Jakob Meineke³, Hendrik Kooijman⁴, Axel Haase², Ernst J. Rummeny⁵, Jan S. Kirschke⁶, Thomas Baum¹, and Dimitrios C. Karampinos⁵

¹Department of Diagnostic and Interventional Radiology, Technische Univeristät München, Munich, Germany, ²Zentralinstitut für Medizintechnik, Technische Universität München, Munich, Germany, ³Philips Research Laboratory, Hamburg, Germany, ⁴Philips Healthcare, Hamburg, Germany, ⁵Department of Diagnostic and Interventional Radiology, Technische Universität München, Munich, Germany, ⁶Section of Neuroradiology, Technische Universität München, Munich, Germany

Trabecular bone imaging has a high clinical significance for predicting fracture risk in patients with osteoporosis. Quantitative susceptibility mapping (QSM) has been recently emerging for mapping diamagnetic and paramagnetic substances. Recent reports attempted to use QSM combined with ultra-short echo time imaging for mapping the susceptibility of cortical bone. However, it remains unknown whether QSM is feasible for measuring bone volume density in trabecular bone, where the bone density is much lower than cortical bone. The purpose of the present work is to study the feasibility of QSM for trabecular bone density mapping, using numerical simulations, specimen measurements and preliminary in vivo measurements.

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