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Abstract #0680

Fast volumetric mapping of bound and pore water content in cortical bone in vivo using 3D Cones sequences

Jun Chen1, Michael Carl2, Hongda Shao1, Eric Chang1, Graeme Bydder1, and Jiang Du1

1Radiology, University of California, San Diego, San Diego, CA, United States, 2GE Healthcare, San Diego, CA, United States

Bone water exists in the form of free water in the Haversian canals or lacunar-canalicular system, as well as bound water either loosely bound to collagen or more tightly bound to mineral. Ultrashort echo time (UTE) sequences with TEs as short as 8 ┬Ás can potentially detect signal from pore water and loosely bound water. In this study, we introduce an approach for fast volumetric mapping of bound and pore water content in vivo using a clinical 3T MR scanner.

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