Abstract #0690

Nigral Iron Distribution in Brain of Parkinson’s Disease: A Combined Structural Voxel-wise and ROI-based Study with Quantitative Susceptibility Mapping

Darrell Ting Hung Li¹, Edward Sai Kam Hui¹, Queenie Chan², Nailin Yao³, Siew-eng Chua⁴, Grainne M. McAlonan^4,5, Shu Leong Ho⁶, and Henry Ka Fung Mak¹

¹Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, ²Philips Healthcare, Hong Kong, Hong Kong, ³Department of Psychiatry, Yale University, New Haven, CT, United States, ⁴Department of Psychiatry, The University of Hong Kong, Hong Kong, Hong Kong, ⁵Department of Forensic and Neurodevelopmental Science, King’s College London, London, United Kingdom, ⁶Department of Medicine, The University of Hong Kong, Hong Kong, Hong Kong

Abnormal nigral iron deposition is considered one of the major biomarkers in Parkinson’s disease (PD). Extensive studies had been performed to evaluate iron concentration in substantia nigra using different in vivo imaging methods. Whole structure ROI-based analysis of basal nuclei is a majority approach in similar studies. In this study, we investigated the distribution of iron in substantia nigra with both voxel-wise and split ROI methods. Location of significant higher iron concentration was identified to be around pars compacta of the substantia nigra in PD brain. The two methods adopted in this study agreed with each other.

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