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Abstract #0696

Influence of pulse length and shape on variable flip angle T1 mapping of the human brain

Yosef Al-Abasse1 and Gunther Helms1

1Medical Radiation Physics, Lund University, Lund, Sweden

Effects of the macromolecular pool are usually neglected in T1 mapping using the variable flip angle (VFA) method. To demonstrate the influence of magnetization transfer (MT) on the estimated T1, VFA experiments were performed using sinc and rect pulses of different pulse lengths (0.5 ms ≤ TRF ≤ 2.0 ms). Substantial variations in T1 (11-21 %) were observed. Longer rect pulses yielded lower T1 values than those obtained by inversion recovery. This can be explained by varying saturation of macromolecules and inherent MT. A simplified model for the influence of TRF on the T1 estimates is suggested for low-power rect pulses.

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