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Abstract #0718

Towards Quantitative Renal MR Blood Oximetry by Combined Monitoring of T2*, T2 and Blood Volume Fraction

Andreas Pohlmann1, Karen Arakelyan1,2, Leili Riazy1, Till Huelnhagen1, Stefanie Kox1, Kathleen Cantow2, Sonia Waiczies1, Bert Flemming2, Erdmann Seeliger2, and Thoralf Niendorf1

1Berlin Ultrahigh Field Facility, Max Delbrueck Center for Molecular Medicine, Berlin, Germany, 2Institute of Physiology, Charite Universitaetsmedizin, Berlin, Germany

Acute kidney injuries are often characterized by tissue oxygen hypoxia. T2*-mapping permits probing renal oxygenation but provides a surrogate rather than a quantitative measure of oxygen saturation. The link between pO2 and T2* is influenced by changes in blood volume fraction (BVf). Monitoring BVf in combination with recently developed quantitative BOLD approaches could permit unambiguous interpretation of renal T2*. To test the feasibility of this new approach we monitored renal T2*/T2 during baseline and short periods of venous occlusion. This was performed in the same animal under naïve conditions and again with USPIO to permit estimation of BVf and SO2.

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