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Abstract #0719

BOLD MRI of human placenta and fetuses under maternal hyperoxygenation in growth restricted twin pregnancies

Jie Luo1,2, Esra Abaci Turk1,2, Carolina Bibbo3, Borjan Gagoski1, Mark Vangel4, Clare M Tempany-Afdhal5, Norberto Malpica6, Arvind Palanisamy7, Elfar Adalsteinsson2,8,9, Julian N Robinson3, and Patricia Ellen Grant1

1Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States, 2Madrid-MIT M+Vision Consortium in RLE, Massachusetts Institute of Technology, Cambridge, MA, United States, 3Maternal and Fetal Medicine, Brigham and Women's Hospital, Boston, MA, United States, 4Department of Radiology, Harvard Medical School, Boston, MA, United States, 5Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States, 6Medical Image Analysis and Biometry Laboratory, Universidad Rey Juan Carlos, Madrid, Spain, 7Division of Obstetric Anesthesia, Brigham and Women's Hospital, Boston, MA, United States, 8Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, 9Harvard- MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

Adequate oxygen transport across the placenta from mother to fetus is critical for fetal growth and development. In this pilot study, BOLD MRI with maternal hyperoxygenation show great potential in differentiating IUGR fetuses from controls. Not only the placentae show significant difference in rate of oxygen uptake, fetal organs also have distinct response to exposure to hyperoxia. Differences between fetal brain and liver responses to hyperoxygenation are observed in some cases, which might suggest variations in fetal hemodynamic autoregulation.

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