Hongliang Sun1, Yanyan Xu1, Kaining Shi2, and Wu Wang1
1Radiology, China-Japan Friendship hospital, Beijing, China, People's Republic of, 2Philips Healthcare China, Beijing, China, People's Republic of
Neoadjuvant chemoradiation therapy (CRT) followed by surgery has been
established as the standard for locally advanced rectal cancer. The
treatment response after CRT is normally evaluated by MRI. However, MRI morphology techniques suffer from
limitations in the interpretation of fibrotic scar tissue and inflammation.
Diffusion weighted MRI has shown its potentially beneficial role for response
evaluation, but with conflicting results. Intravoxel incoherent motion
(IVIM) which enable quantitative parameters that separately reflect tissue
diffusivity and tissue microcapillary perfusion[3-4]. However, the pretreatment
tumor IVIM MRI parameters predicting treatment response were not clarified.