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Abstract #0731

Altered Cortical and Subcortical Structures and Structural Connectivity in Perinatally HIV-infected Children

Santosh Kumar Yadav1, Rakesh Kumar Gupta2, Ravindra Kumar Garg3, Vimala Venkatesh4, Ena Wang1, Francesco M Marincola1, and Mohammad Haris1

1Division of Translational Medicine, Sidra Medical and Research Center, Doha, Qatar, 2Department of Radiology, Fortis Memorial Research Institute, Gurgaon, India, 3Department of Neurology, King George Medical University, Lucknow, India, 4Department of Microbiology, King George Medical University, Lucknow, India

Cortical thickness, subcortical volumes and structural brain connectivity changes in HIV-seropositive children were evaluated in comparison to HIV-seronegative children. HIV-seropositive children showed altered cortical thicknesses, subcortical volumes and structural connectivity compared to those of HIV-seronegative children. In addition, changes in cortical and subcortical structures were significantly correlated with CD4+ counts and neuropsychological scores in HIV-seropositive children. We suggest that neuronal injury due to HIV-infection and inflammation might be possible reasons for the altered cortical thickness, subcortical volumes and connectivity in these patients.

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