Melissa Tamara Hooijmans1, Melissa Tamara Hooijmans1, Nathalie Doorenweerd1, Jedrek Burakiewicz1, Andrew Webb1, Jan Vershuuren2, Erik Niks2, and Hermien Kan1
1Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Neurology, Leiden University Medical Center, Leiden, Netherlands
Quantitative MRI and
MRS are increasingly important as non-invasive and objective outcome measures
in therapy development for DMD. Several MR indices, have been shown to
correlate individually with age and functional measures. However, much less
attention has been given to how these indices relate to each other. Our work
combined quantitative MRI and spatially resolved 31P MRS in the
lower leg muscles of DMD patients and showed that combining multimodal MR
measures is very important to objectively assess muscle degeneration
processes and potentially the effect of therapeutic interventions in DMD.
