31P-MRI using A Spectrally Selective 3D non-Cartesian FLORET Sequence at 7 T
Prodromos Parasoglou1, Ryan Brown1,2, and Guillaume Madelin1
1Department of Radiology, New York University School of Medicine, New York, NY, United States, 2NYU WIRELESS, Polytechnic Institute of New York University, Brooklyn, NY, United States
We developed a spectrally selective 3D non-Cartesian FLORET
pulse sequence to map phosphorus-containing metabolites in the human tissue. In
particular, through this highly efficient pulse sequence we mapped
phosphocreatine and γ-adenosine triphosphate at
1.4 cm isotropic nominal voxel size in the human brain. In addition, we were
able to map phosphocreatine in the skeletal muscle during exercise and recovery
with 6 s temporal resolution. We showed that spectrally selective 3D-FLORET is
an efficient pulse sequence that can be used to image 31P-containing
metabolites in the human tissue when high spatiotemporal resolution is needed.
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