Abstract #0776

MRI monitoring of epileptogenesis with direct histological validation

Niels Leonard Schwaderlapp¹, Philipp Janz², Ute Häussler², Jan Korvink³, Dominik Elverfeldt¹, Jürgen Hennig¹, Carola Haas², and Pierre LeVan¹

¹Medical Physics, University Medical Center Freiburg, Freiburg, Germany, ²Experimental Epilepsy Research, University Medical Center Freiburg, Freiburg, Germany, ³Institut für Mikrostrukturtechnik, Karlsruher Institut für Technologie, Karlsruhe, Germany

Cellular-level pathological changes in the kainate mouse model of temporal lobe epilepsy (TLE) have been well-characterized immunohistochemically (IHC) and include neuronal injury followed by granule cell dispersion. In this work, we demonstrate the possibility to non-invasively track granule cell dispersion and neuronal injury using diffusion imaging and ¹H-spectroscopy. The volume of the dispersed granule cell layer quantified by DTI and the initial injury reflected by a reduction of NAA and glutamate are quantitatively validated with IHC and can be used as early markers of epileptogenicity in this mouse model of TLE.

This abstract and the presentation materials are available to members only; a login is required.

Join Here