Abstract #0804

A new NOE-mediated MT signal at -1.6 ppm for detecting ischemic stroke in rat brain

Xiaoyong Zhang^1,2, Feng Wang^1,2, Aqeela Afzail³, John C. Gore^1,2, Daniel F Gochberg^1,2, and Zhongliang Zu^1,2

¹Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ²Depatment of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, ³Department of Neurological Surgery, Vanderbilt University, Nashville, TN, United States

We recently reported a new NOE-mediated MT signal at around -1.6 ppm, named NOE(-1.6). In the present work, we evaluated the changes of this signal that occur early in ischemic stroke and found that both NOE(-1.6) and Amide Proton Transfer (APT) signals from stroke lesions have significant changes after MCAO. Compared with APT, NOE(-1.6) showed much stronger contrast between stroke and contralateral normal tissues. We conclude that a new NOE(-1.6) signal in rat brain could be used as a biomarker for assessment of acute ischemic stroke.

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