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Abstract #0808

Transit time mapping in the mouse brain using time-encoded pCASL

Lydiane Hirschler1,2,3, Leon P. Munting4,5, Wouter M. Teeuwisse4, Ernst Suidgeest4, Jan M. Warnking1,2, Matthias J. P. van Osch4, Emmanuel L. Barbier1,2, and Louise van der Weerd4,5

1Grenoble Institut des Neurosciences, Université Grenoble Alpes, Grenoble, France, 2Inserm U836, Grenoble, France, 3Bruker Biospin, Ettlingen, Germany, 4Radiology, Leiden University Medical Center, Leiden, Netherlands, 5Human Genetics, Leiden University Medical Center, Leiden, Netherlands

Arterial transit time (ATT) is known to influence CBF-quantification and is interesting in itself, as it may reflect underlying vascular pathologies. Currently, no MRI sequence exists to measure ATT in mice. Recently, time-encoded labeling schemes have been implemented in rats and men, enabling ATT-mapping with higher SNR and less scan-time than multi-delay ASL. In this study, we show that time-encoded pCASL (te-pCASL) enables transit times measurements in mice. Furthermore, ATT was found to be preserved in old WT mice.

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