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Abstract #0827

The potential of apparent diffusion coefficient in differentiating various sub-types of breast tumors and its association with hormonal status

Khushbu Agarwal1, Rani Gupta Sah1, Uma Sharma1, Smriti Hari2, Sandeep Mathur3, Vurthaluru Seenu4, Rajinder Parshad4, and Naranamangalam R Jagannathan1

1Department of NMR and MRI Facility, All India Institute of Medical Sciences, Delhi, India, 2Department of Radio-diagnosis, All India Institute of Medical Sciences, Delhi, India, 3Department of Pathology, All India Institute of Medical Sciences, Delhi, India, 4Department of Surgical Disciplines, All India Institute of Medical Sciences, Delhi, India

Potential of apparent diffusion coefficient (ADC) in differentiating various sub-types of malignant and benign breast tumors using diffusion weighted MRI and its association with different hormonal status in breast cancer patients was studied. A significantly lower ADC of malignant compared to benign and healthy breast tissues was observed. The ADC of fibroadenomas was lower compared to fibrocystic with fibroadenoma and cystic lesions and higher in cystic and fibrocystic lesions than benign ductal epithelial cells. No association of ADC with molecular biomarkers ER, PR and Her2neu was seen. Results showed the utility of ADC in differentiating various types of breast tissues.

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