Meeting Banner
Abstract #0839

Hyperpolarized [1-13C]-Pyruvate Differentiates Distinctive Molecular Phenotypes in Diffuse Intrinsic Pontine Gliomas

Ilwoo Park1, Rintaro Hashizume2, Joanna Phillips3,4, Sabine Mueller3,5, and Sarah Nelson1,6

1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Neurological Surgery, Northwestern University, Chicago, IL, United States, 3Neurological Surgery, University of California San Francisco, San Francisco, CA, United States, 4Pathology, University of California San Francisco, San Francisco, CA, United States, 5Pediatrics, University of California San Francisco, San Francisco, CA, United States, 6Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, United States

Diffuse intrinsic pontine gliomas (DIPGs) are one of the most difficult pediatric cancers to treat. This study investigated the feasibility of 13C magnetic resonance spectroscopic imaging (MRSI) of hyperpolarized (HP) [1-13C]pyruvate for differentiating molecular characteristics of DIPGs. Differences in the lactate signal that were observed in two distinct biopsy-originated orthotopic DIPG tumors were associated with changes in the levels of LHDA and HIF-1α activity. This suggests that the non-invasive characterization of DIPGs using this new neuroimaging method may be helpful for assessing treatment response and tumor progression.

This abstract and the presentation materials are available to members only; a login is required.

Join Here