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Abstract #0864

Gauging the Effectiveness of Traumatic Brain Injury Treatment using MR Phase Gradient Mapping

Gregory Simchick1,2, Martha Betancur3,4, Lohitash Karumbaiah3,4, and Qun Zhao1,2

1Physics, University of Georgia, Athens, GA, United States, 2Bio-Imaging Research Center, Athens, GA, United States, 3Animal and Dairy Science, University of Georgia, Athens, GA, United States, 4Regenerative Bioscience Center, Athens, GA, United States

Due to both short-term and long-term effects, traumatic brain injuries (TBIs) have been a growing topic of interest over the last several years; therefore, research related to the development of new methods to treat and monitor these types of injuries has also gained interest. Presented here is a non-invasive method using magnetic resonance (MR) phase gradient mapping (PGM) to characterize TBI treatment in relation to regional cerebral blood flow (rCBF) in angiogenesis and tissue loss. In a rat moderate-to-severe TBI model, increases between 16-29% in rCBF were seen in the treatment group twenty weeks post TBI, while decreases between 9-27% in rCBF were seen in the non-treatment group.

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