MRI assessment of aortic flow in patients with pulmonary hypertension in response to exercise
Jacob Macdonald1, Omid Forouzan2, Naomi Chesler2, Christopher Francois3, and Oliver Wieben1,3
1Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, 2Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States, 3Radiology, University of Wisconsin - Madison, Madison, WI, United States
Cardiopulmonary exercise testing is gaining increased
recognition as a useful tool for assessing pulmonary hypertension (PH). Using
an MRI-compatible exercise device that allows subjects to exercise in the bore
of the magnet, we investigated the effects of exercise stress on blood flow in
the ascending aorta in healthy controls and patients with PH. The measurements
we obtained demonstrated a decreased exercise capacity in PH subjects and in
older controls. Some parameters, such as cardiac output, demonstrated
statistically significant changes between rest and stress, while others were
unclear due to the relatively low exercise power tolerated by the PH patients.
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