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Abstract #0899

3D Dynamic Hyperpolarized 13C-Pyruvate MR Metabolic Imaging of Human Prostate Cancer

Hsin-Yu Chen1, Peder E.Z. Larson1,2, Jeremy W. Gordon2, Robert A. Bok2, Marcus Ferrone3, Mark van Criekinge2, Lucas Carvajal2, Peng Cao2, Ilwoo Park2, Rahul Aggarwal4, Sarah J. Nelson1,2, John Kurhanewicz1,2, and Daniel B. Vigneron1,2

1Graduate Program in Bioengineering, UCSF and UC Berkeley, University of California, San Francisco, San Francisco, CA, United States, 2Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 3Department of Clinical Pharmacy, University of California, San Francisco, San Francisco, CA, United States, 4Department of Medicine, Division of Hematology/Oncology, University of California, San Francisco, San Francisco, CA, United States

To measure the 3D spatial and temporal dynamics of hyperpolarized [1-13C]pyruvate for patient studies, a new compressed-sensing EPSI sequence was developed for prostate cancer clinical research. Utilizing multiband, variable flip angle RF excitation, this sequence provided high temporal (2s) and spatial (0.5cm3) resolution data detecting pyruvate uptake and its rate of conversion to lactate. This approach provided a significant advance over initial human HP-13C studies in which just 1D or 2D dynamics were measured and 15s single-timepoint 3D spectra were acquired. Following phantom tests, patient data demonstrated high pyruvate to lactate conversion in regions corresponding to biopsy-confirmed prostate cancer.

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