Abstract #0956

Brain connectivity of glioblastoma patients using MR-PET and DTI data

Ana Carina Mendes¹, Ana-Maria Oros-Peusquens², André Santos Ribeiro^1,3, Karl-Josef Langen², Carolin Weiß Lucas⁴, Nadim Jon Shah², and Hugo Alexandre Ferreira¹

¹Institute of Biophysics and Biomedical Engineering, Faculty of Sciences of the University of Lisbon, Lisbon, Portugal, ²Forschungszentrum Juelich GmbH, Institute of Neurosciences and Medicine-INM4, Juelich, Germany, ³Centre for Neuropsychopharmacology, Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom, ⁴Center of Neurosurgery, University of Cologne, Cologne, Germany

Methods capable of mapping brain connectivity pathways may prove useful by providing valuable information in order to prevent sequelae following a surgical intervention. This study presents an approach for the whole-brain connectivity evaluation of nine patients with lateralized gliobastoma, using the Multimodal Imaging Brain Connectivity Analysis (MIBCA) toolbox to process MR and PET data. Results show changes in connectivity metrics across both hemispheres for all patients accompanied by an increased number of fibres which may result from reorganization of connectivity pathways caused by the disruption of the original ones by the tumour.

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