Discrimination of COPD Patients, Healthy Smokers and Age-matched Normals with Hyperpolarized Xenon-129 MR Spectroscopy
Kai Ruppert1,2, Kun Qing2, Talissa A. Altes2,3, and John P. Mugler III2
1Cincinnati Children's Hospital, Cincinnati, OH, United States, 2University of Virginia, Charlottesville, VA, United States, 3University of Missouri, Columbia, MO, United States
Chemical Shift Saturation Recovery (CSSR) MR Spectroscopy permits the in-vivo measurement of the alveolar septal wall thickness (SWT) by quantifying the uptake of hyperpolarized xenon-129 by lung parenchyma on a millisecond timescale. In this study we correlated the SWT with apparent diffusion coefficient (ADC) measurements in patients with chronic-obstructive pulmonary disease (COPD), healthy smokers and age-matched normals. While the ADC measurements and conventional pulmonary function tests could detect statistically significant differences between the COPD and non-COPD subjects, only CSSR spectroscopy could, in addition, discriminate healthy smokers from the age-matched normals.
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