MR Imaging of Liver Microstructure in Hepatic Fibrosis and Cirrhosis at 11.7 T
Mark Valasek1, Qun He2,3, Claude Sirlin2, Graeme M. Bydder2, and Nikolaus M. Szeverenyi2
1Pathology, University of California, San Diego, San Diego, CA, United States, 2Radiology, University of California, San Diego, San Diego, CA, United States, 3Ningbo Jansen NMR Technology Co., Ltd., Cixi, Zhejiang, China, People's Republic of
We performed MR microscopy at 11.7 T to examine the tissue
structure of normal, fibrotic and cirrhotic liver samples. Images having
100-1,000 times the spatial resolution of clinical MR images were obtained in small
tissue samples using an animal imaging system with appropriately small custom T/R
solenoid coils. Diffusion imaging with three direction of sensitization revealed
sheet like fibrous structures, exhibiting high signal intensity in regions
where the sensitization direction was orthogonal to a sheet.
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