Abstract #0997

Comprehensive assessments of myocardial tissue kinetic parameters of K1, k2, MBF, lambda and ECV by using a synergistic quantitative analysis of first-pass myocardial perfusion MRI and pre-and post-contrast T1 mapping in patients with myocardial infarction.

Akimasa Yamada¹, Masaki Ishida¹, Takashi Ichihara², Takahiro Natsume², Yoshitaka Goto¹, Mio Uno¹, Motonori Nagata¹, Yasutaka Ichikawa¹, Kakuya Kitagawa¹, and Hajime Sakuma¹

¹Radiology, Mie University Hospital, Tsu-Mie, Japan, ²Faculty of Radiological Technology, Fujita Health University School of Health Science, Toyoake-Aichi, Japan

In this study, we proposed a new method that synergistically analyzes quantitative perfusion MRI and T1-mapping for quantifying k2, as well as K1, myocardial blood flow, lambda and extracellular volume fraction. Nineteen patients with previous myocardial infarction (MI) were studied. Myocardial segments were categorized into 3 groups by presence or absence as well as severity of MI in each segment. Quantitative measurement was successful in all segments with significant difference among the 3 groups of myocardial segments for all tissue kinetic parameters including k2. Synergistic assessment of quantitative perfusion MRI and T1-mapping is promising for more detailed myocardial tissue characterization.

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