Comparing Single-Delay, Sequential Multi-delay, and Hadamard Multi-delay ASL for Measuring CBF and Arterial Transit Delay in Normal Subjects and Patients with Cerebrovascular Disease
Samantha Holdsworth1, Audrey Fan1, Marc Lebel2, Zungho Zun3, Ajit Shankaranarayanan4, and Greg Zaharchuk1
1Department of Radiology, Stanford University, Stanford, CA, United States, 2GE Healthcare, Calgary, Canada, 3George Washington University, Washington, DC, United States, 4GE Healthcare, Menlo Park, CA, United States
One promising approach to multi-delay ASL is to perform the
labeling using a Hadamard-encoded method, which promises to improve the SNR
efficiency compared with sequential multi-delay ASL. In this study, we compared single-delay ASL,
sequential multi-delay ASL, and Hadamard-encoded multi-delay ASL in normal
subjects and in patients with cerebrovascular disease. Consistent with theory, Hadamard-encoding had
better SNR than sequential multi-delay ASL for measuring CBF and arterial
transit delay.
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