Abstract #1009

Incorporation of labeling efficiency measurement into a normal pCASL perfusion scan without SNR-penalty

Zhensen Chen¹, Xihai Zhao¹, Wouter Teeuwisse², Bida Zhang³, Peter Koken⁴, Jouke Smink⁵, and Matthias J.P. van Osch²

¹Certer for Biomedical Imaging Research, School of Medicine, Tsinghua University, Beijing, China, People's Republic of, ²C. J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ³Philips Research China, Beijing, China, People's Republic of, ⁴Innovative Technologies, Research Laboratories, Philips Technologie GmbH, Hamburg, Germany, ⁵Philips Healthcare, MR Clinical Science, Best, Netherlands

The pCASL perfusion sequence was modified to incorporate a labeling efficiency measurement during the post-labeling delay. Our in vivo data showed that the incorporated labeling efficiency measurement had no influence on SNR of the perfusion measurements, with almost no additional time penalty. The additional labeling efficiency measurement was demonstrated its ability to identify severe underestimation of CBF caused by sub-optimal labeling, proofing its clinical potential. Moreover, the measured labeling efficiency is artery-specific, which is important because arteries may have different labeling efficiency due to differences in flow velocity and/or off-resonance effects.

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