Jinjin Zhang1, Hattie L. Ring1, Michael Garwood1, and Djaudat Idiyatullin1
The ability to accurately and
sensitively quantify the bio-distribution of iron oxide nanoparticles is
essential for their use as both diagnostic and therapeutic agents in theranostics.
In this study, a 4D spectroscopic SWIFT technique was applied and optimized to characterize
the distribution of IONPs in mouse invivo up to high concentration (>1.0 mg Fe/g of tissue). The frequency shift due to susceptibility variation and T2*
shortening (down to 20 μs) caused by IONPs were detected in mice organs depositing IONPs. The acquired T2* map which provide quantitative information about IONP bio-distribution makes the 4D spectroscopic SWIFT a promising tool in nanoparticle-based theranostics.