Qiuyun Fan1, Aapo Nummenmaa1, Jonathan R. Polimeni1, Thomas Witzel1, Susie Y. Huang1, Van J. Wedeen1, Bruce R. Rosen1,2, and Lawrence L. Wald1,2
1Massachusetts General Hospital, Boston, MA, United States, 2Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, United States
The
cerebral cortex is rich in gyral folding. Axonal fibers take sharp turns when
bending into the cortex. High resolution
diffusion MRI is needed to characterize cortical structures in finer scale,
while high b-value is desired to
resolve complex white matter structures. We examined the impact of imaging
resolution on characterizing the radial diffusion pattern in cortex, and
proposed to improve the HIgh B-value and high Resolution Integrated Diffusion (HIBRID) imaging by incorporating information
about each voxel’s proximity to the cortex. The combined data demonstrated the
desired features from both high resolution and high b-value diffusion imaging.
