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Abstract #1050

Evaluation of Renal Blood flow in subjects with Diabetic Nephropathy using ASL Perfusion MRI

Lu-Ping Li1,2, Huan Tan1, Jon Thacker3, Wei Li1,2, Ying Zhou4, Orly Kohn5, Stuart Sprague2,6, and Pottumarthi V Prasad1,2

1Radiology, Northshore University HealthSystem, Evanston, IL, United States, 2Pritzker School of Medicine, University of Chicago, Chicago, IL, United States, 3Biomedical Engineering, Northwestern University, Evanston, IL, United States, 4Center for Biomedical Research & Informatics, Northshore University HealthSystem, Evanston, IL, United States, 5Medicine, University of Chicago, Chicago, IL, United States, 6Medicine, Northshore University HealthSystem, Evanston, IL, United States

Renal blood flow is thought to be reduced in subjects of diabetic nephropathy (DN). However, there is limited amount of quantitative data on renal blood flow in patients with DN. In this study, ASL MRI data was acquired in 28 patients with diabetes and stage-3 CKD along with 30 healthy controls. Renal blood flow was found to be significantly lower in subjects with DN with a large Cohen’s d value. Renal blood flow also showed a significant correlation with eGFR and age was not found to be a significant confounder in this relationship.

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