Abstract #1057

MR-derived indices for identification of quantity and distribution of adipose tissue – age- and gender related differences in a cohort at increased risk for metabolic diseases

Jürgen Machann¹, Malte Niklas Bongers², Andreas Fritsche³, Norbert Stefan³, Hans-Ulrich Häring³, Konstantin Nikolaou⁴, and Fritz Schick²

¹Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, IDM of the Helmholtz Center Munich at the University Tübingen, German Center for Diabetes Research (DZD), Tuebingen, Germany, ²Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Hospital Tuebingen, Tuebingen, Germany, ³Department of Endocrinology and Diabetology, Angiology, Nephrology and Clinical Chemistry, IDM of the Helmholtz Center Munich at the University Tübingen, German Center for Diabetes Research (DZD), Tuebingen, Germany, ⁴Department of Diagnostic and Interventional Radiology, University Hospital Tuebingen, Tuebingen, Germany

MR-based phenotyping is of increasing interest for cross-sectional and interventional studies on large cohorts. Quantification of adipose tissue (AT) compartments – e.g. by T1-weighted MRI – has mainly been performed by giving the absolute amounts in litres. However, this does not directly reflect the distribution and quantity (e.g. for people with different size). Thus, the percentage of AT compartments are given as percent of total AT and new fat indices, corrected for height (comparable to BMI) are introduced and age- and gender related differences are determined in a large cohort of people at increased risk for metabolic diseases.

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