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Abstract #1059

TOFI – Thin Outside, Fat Inside – identifying non-obese subjects at high risk for metabolic diseases based on MRI and MRS

Jürgen Machann1, Malte Niklas Bongers2, Norbert Stefan3, Andreas Fritsche3, Konstantin Nikolaou4, Hans-Ulrich Häring3, and Fritz Schick5

1Section on Experimental Radiology, IDM of the Helmholtz Center Munich at the University Tübingen, German Center for Diabetes Research (DZD), Tuebingen, Germany, 2Department of Diagnostic and Interventional Radiology, Section on Experimental Radiology, Tuebingen, Germany, 3Department of Endocrinology and Diabetology, Angiology, Nephrology and Clinical Chemistry, IDM of the Helmholtz Center Munich at the University Tübingen, German Center for Diabetes Research (DZD), Tuebingen, Germany, 4Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tuebingen, Germany, 5Section on Experimental Radiology, University Hospital Tübingen, Tuebingen, Germany

Axial T1-weighted MRI and volume selective 1H-MRS were performed in a cohort of almost 500 non-obese subjects at increased risk for metabolic diseases. Adipose (AT) and lean tissue (LT) compartments from different body regions were quantified and are expressed as percentage of the entire volume in order to display tissue distribution and to differentiate metabolically healthy (insulin sensitive, IS) and unhealthy (insulin resistant, IR) subgroups. Additionally, intrahepatic lipids (IHL) were quantified. It could be shown that IS subjects are characterized by lower percentage of AT in abdominal regions but higher amounts in the extremities whereas IHL are almost doubled in IR subjects.

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