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Abstract #1078

Multi-compartment microscopic diffusion anisotropy imaging brought into clinical practice

Enrico Kaden1, Nathaniel D. Kelm2, Robert P. Carson3, Mark D. Does2, and Daniel C. Alexander1

1Centre for Medical Image Computing, University College London, London, United Kingdom, 2Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 3Departments of Neurology and Pediatrics, Vanderbilt University, Nashville, TN, United States

This work introduces a multi-compartment model for microscopic diffusion anisotropy imaging using an off-the-shelf pulse sequence achievable on standard clinical scanners. In particular, we will provide estimates of microscopic features specific to the intra- and extra-neurite compartments unconfounded by the effects of fibre crossings and orientation dispersion, which are ubiquitous in the brain. The new imaging technique is demonstrated in a large cohort of healthy young adults as well as for the detection of microstructural tissue alterations in a preclinical animal model of tuberous sclerosis complex.

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