Abstract #1135

White Matter Swelling Masked Axonal Loss Detected by Diffusion Basis Spectrum Imaging (DBSI)

Tsen-Hsuan Lin¹, Mitchell Hallman^1,2, Fay Hwang¹, Yong Wang^1,3,4,5, Sheng-Kwei Song^1,4,5, and Peng Sun¹

¹Radiology, Washington University School of Medicine, St. Louis, MO, United States, ²Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, ³Obstertic and Gynecology, Washington University School of Medicine, St. Louis, MO, United States, ⁴The Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, United States, ⁵Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, United States

The extent of axonal loss plays a significant role in irreversible neurological impairment in spinal cord injury (SCI). We detected a 15% axonal loss in SCI mice using diffusion basis spectrum imaging (DBSI) that was masked by injury induced white matter swelling.

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