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Abstract #1142

CEST Imaging Targeted APT vs. FDG-PET/CT: Capability for Differentiating Malignant from Benign Pulmonary Lesions

Yoshiharu Ohno1,2, Masao Yui3, Mitsue Miyazaki4, Yuji Kishida2, Shinichiro Seki2, Hisanobu Koyama2, Katsusuke Kyotani5, Takeshi Yoshikawa1,2, and Kazuro Sugimura2

1Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, Kobe, Japan, 2Radiology, Kobe University Graduate School of Medicine, Kobe, Japan, 3Toshiba Medical Systems Corporation, Otawara, Japan, 4Toshiba Medical Research Institute USA, Vernon Hills, IL, United States, 5Center for Radiology and Radiation Oncology, Kobe University Hospital, Kobe, Japan

Chemical exchange saturation transfer (CEST) imaging is suggested as a new technique for MR-based molecular imaging techniques in vivo and in vitro studies. We hypothesized that newly developed CEST imaging, may have a similar potential for differentiating malignant from benign pulmonary nodules and masses, when compared with FDG-PET/CT. The purpose of this study was to directly and prospectively compare the capability of CEST imaging targeted to amide groups (-NH) for differentiation of malignant from benign pulmonary lesions with FDG-PET/CT.

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