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Abstract #1146

129Xe pulmonary gas exchange spectroscopy in idiopathic pulmonary fibrosis

Scott H. Robertson1,2, Elianna A. Bier1,2, Rohan S. Virgincar1,3, and Bastiaan Driehuys1,2,3,4

1Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC, United States, 2Medical Physics Graduate Program, Duke University, Durham, NC, United States, 3Department of Biomedical Engineering, Duke University, Durham, NC, United States, 4Department of Radiology, Duke University Medical Center, Durham, NC, United States

Accurately characterizing the chemical shifts of 129Xe in the lung, enables probing pulmonary gas exchange at the micron scale interface between the alveoli and capillary beds. Doing so requires decomposing the dissolved phase 129Xe spectrum. Whereas previous work identified only two dissolved-phase 129Xe resonances associated with blood and barrier tissues, we now employ improved non-linear fitting techniques to decompose complex FIDs into three resonances. This enables us to report updated ratios of 129Xe uptake in blood and barrier resonances, many of which differ significantly between control and IPF groups.

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