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Abstract #1167

Evaluation of 3D T1-weighted imaging at 3 T across scanner vendors and models

Sjoerd B Vos1,2, M Jorge Cardoso1, Marzena Wylezinska-Arridge3, David L Thomas1,3, Enrico De Vita3,4, Marios C Yiannakas5, David Carmichael6, John S Thornton3,4, Olga Ciccarelli5, John S Duncan2,7, and Sebastien Ourselin1

1Translational Imaging Group, University College London, London, United Kingdom, 2MRI Unit, Epilepsy Society, Chalfont St Peter, United Kingdom, 3Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom, 4Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom, 5Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom, 6Institute of Child Health, University College London, London, United Kingdom, 7Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, United Kingdom

Volumetric analyses of 3D T1-weighted images has become an integral part of the clinical work-up and research studies. Variation between scanners, in both vendors and models, is a major confound in combining imaging-derived biomarkers across sites. In this work, we analyse test-retest data from different days on six 3 T scanners from three vendors to quantify this inter-scanner variability compared to intra-scanner variability. Contrast-to-noise ratios as well as volumetric analyses are performed showing between-scanner variation in total brain volumes – indicating different scanner calibrations – but also tissue-specific differences – possibly arising from different effective contrasts.

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