Abstract #1187

Regional Brain Myelin Mapping in Patients with Obstructive Sleep Apnea

Sudhakar Tummala¹, Bumhee Park¹, Ruchi Vig¹, Mary A Woo², Daniel W Kang³, Ronald M Harper^4,5, and Rajesh Kumar^1,5,6,7

¹Anesthesiology, University of California at Los Angeles, Los Angeles, CA, United States, ²UCLA School of Nursing, Los Angeles, CA, United States, ³Medicine, University of California at Los Angeles, Los Angeles, CA, United States, ⁴Neurobiology, University of California at Los Angeles, Los Angeles, CA, United States, ⁵Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, United States, ⁶Radiological Sciences, University of California at Los Angeles, Los Angeles, CA, United States, ⁷Bioengineering, University of California at Los Angeles, Los Angeles, CA, United States

Obstructive sleep apnea (OSA) patients show gray matter injury in multiple brain areas based on various MRI techniques, which can accompany subcortical and white matter myelin integrity loss in the condition. However, the extent of regional myelin changes in OSA is unclear. We examined regional myelin integrity in newly-diagnosed, treatment-naive OSA patients, and found decreased values, probably resulting from hypoxic/ischemic processes, in critical autonomic, cognitive, respiratory, and mood control sites, functions that are deficient in the condition. These findings show that myelin mapping, based on the ratio of T1- and T2-weighted images, is useful in assessing regional myelin alterations.

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