Abstract #1189

Brain bioenergetics as markers of vigilance failure in obstructive sleep apnoea

Caroline D Rae¹, Haider Naqvi², Andrew Vakulin^2,3, Angela D'Rozario², Michael Green¹, Hannah Openshaw², Keith Wong^2,4, Jong-Won Kim⁵, Delwyn J Bartlett⁶, Doug McEvoy⁷, and Ronald R Grunstein⁶

¹The University of New South Wales, Randwick, Australia, ²NHMRC Centers of Research Excellence, CIRUS and NeuroSleep, Woolcock Institute of Medical Research, The University of Sydney, Sydney, Australia, ³3. Adelaide Institute for Sleep Health: A Flinders Centre of Research Excellence, School of Medicine, Flinders University, Adelaide, Australia, ⁴Sydney Medical School, The University of Sydney, Sydney, Australia, ⁵School of Physics, The University of Sydney, Sydney, Australia, ⁶NeuroSleep and Woolcock Institute of Medical Research, The University of Sydney, Sydney, Australia, ⁷Adelaide Institute for Sleep Health: A Flinders Centre of Research Excellence, School of Medicine, Flinders University, Adelaide, Australia

Here, we investigated the potential for MRS/MRI markers to differentiate between phenotypes of obstructive sleep apnea patients who are vulnerable, versus resistant to vigilance failure, an indicator of driving impairment and accident risk. Vulnerable patients (N = 15) and resistant patients (N = 30) were differentiated on the basis of left orbito-frontal glutamate and aspartate and also anterior cingulate glutathione levels. There was a trend towards lower orbitofrontal creatine levels in vulnerable OSA subjects, but no group differences in brain volumes.

This abstract and the presentation materials are available to members only; a login is required.

Join Here