Radhika Madhavan1, Suresh E Joel1, Sumit Niogi2, John A Tsiouris2, Luca Marinelli3, and Teena Shetty2
1GE Global Research, Bangalore, India, 2Hospital for special surgery, New York, NY, United States, 3GE Global Research, Niskayuna, NY, United States
mTBI diagnosis is controversial since although the
brain appears normal on CT/MRI scans, a
significant proportion of patients display persistent cognitive impairments up
to 6 months post-injury. We recorded rs-fMRI in mTBI patients longitudinally over
3 months, to track functional changes in the brain as patients recovered.
Symptom scores were negatively correlated with fractional power in the low-frequency
band (0.01-0.1 Hz) of rs-fMRI, and this correlation was most significant in the
higher visual, salience and sensorimotor networks. We suggest that low
frequency power of rs-fMRI can be used as a biomarker for predicting severity
of cognitive impairment in brain injury.