Volumetric analysis of structural brain changes in acute and sub-acute mild traumatic brain injury
Tianhao Zhang1, Sumit Niogi2, John A. Tsiouris2, Luca Marinelli3, and Teena Shetty4
1GE Healthcare, Waukesha, WI, United States, 2Weill Cornell Medical Center, New York, NY, United States, 3GE Global Research, Niskayuna, NY, United States, 4Hospital for Special Surgery, New York, NY, United States
Mild traumatic brain injury (mTBI) is a heterogeneous disease with a variety of symptoms associated with brain function alterations after the trauma. There is still limited understanding of the relationship between physiological and structural changes and recovery rate. In this work, we aim to identify structural brain changes in a mTBI population at 4 time points. The analysis is in two folds: 1) correlation analysis between brain volumes and clinical scores; and 2) longitudinal analysis across different encounters. The results revealed significant brain volume changes over time, and at 3 months post-injury, volumes demonstrated significant negative correlations with clinical scores.
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