The basis of Parkinson disease (PD) pathology is accumulation of α-synuclein particles (Lewy bodies) in the presynaptic terminal and perikaria of neocortex, cerebellum, thalamus and SN.
Features of the lipid profile specially cholesterol levels are association with PD risk. However no such data exists on the association of these plasma markers with structural brain changes in PD. The primary site of PD pathology is the nigrostriatal tract which then progresses to the cingulium. The nigrostriatal tract is extensively damaged prior to PD onset. Lower plasma levels of apoA-I is associated with earlier onset of PD and greater putaminal DAT deficit and a more rapid motor decline in PD . However apoA-I levels have never been investigated regarding changes in structural brain connectivity. The our results show that apoA-I levels in drug_naïve patients are associated with structural changes in the even prior to pathologic involvement of cingulium.